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Fig. 3 | Respiratory Research

Fig. 3

From: Mesenchymal stromal cell-derived exosomes improve pulmonary hypertension through inhibition of pulmonary vascular remodeling

Fig. 3

Effects of MSC-exo on MCT-induced endothelial-to-mesenchymal transition. a Representative immunofluorescence staining with a-SMA (Red) and the cell nuclei were labeled with DAPI (blue) in the pulmonary arterioles using a light microscope at a × 400 magnification. b Comparative analysis of non-muscularized vessels, partially muscularized vessels, and fully muscularized vessels. c Protein expression of CD31 and a-SMA analysis by western blot in lungs. d Detection and comparative analysis of the protein expression of Wnt5a, β-catenin and cyclin D1. n = 5 rats per group; P < 0.05, t-test; the data are present as mean ± SD; *MCT or *MSC-CM vs. control; #MSC-exo vs. MCT group; scale bar = 100 μm

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Respiratory Research

ISSN: 1465-993X

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