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Fig. 3 | Respiratory Research

Fig. 3

From: Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

Fig. 3

Network of pro-inflammatory cytokines and matrix metalloproteinases differentially expressed after treatment with CHF6001 A) 800 μg and B) 1600 μg BID relative to placebo. Each node represents all the proteins produced by a single, protein-coding gene locus, edges represent proteins that jointly contribute to a shared function, and the information inside the circle describes protein structure. Edges: a red line indicates the presence of fusion evidence; a green line, neighbourhood evidence; a blue line, co-occurrence evidence; a magenta line, experimental evidence; a yellow line, text mining evidence; a light blue line, database evidence; a black line, co-expression evidence; a purple line, protein homology evidence. A green halo around the nodes: downregulation, a red halo: upregulation. Unmarked nodes: pFDR< 0.05; * on the nodes: p < 0.05 and |FC| > 1.3

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