Fig. 1

Differentially expressed probe sets for CHF6001 800 μg and 1600 μg BID relative to placebo in (A) blood and (B) sputum. Volcano plot depicting all detected probe sets and coloured by fold change (FC) and adjusted p-values: orange, |FC| > 1.3; red, pFDR< 0.05; green, |FC| > 1.3 and pFDR< 0.05. Abbreviation: BID, twice daily