| Non-HFNT PR | HFNT PR | Between-group test | |||||
---|---|---|---|---|---|---|---|---|
Baseline (n = 22) | 4 weeks (n = 22) | 12 weeks (n = 22) | Baseline (n = 22) | 4 weeks (n = 22) | 12 week (n = 22) | 4 weeks | 12 weeks | |
p value | ||||||||
Pulmonary function test | ||||||||
 FVC, L | 2.29 ± 0.76 | 2.38 ± 0.73**a | 2.40 ± 0.74**a | 2.26 ± 0.68 | 2.38 ± 0.69 | 2.42 ± 0.69 | 0.990 | 0.932 |
 FEV1, L | 0.83 ± 0.24 | 0.84 ± 0.23 | 37.5 ± 39.6 | 0.86 ± 0.26 | 0.88 ± 0.26 | 0.92 ± 0.26**a,b | 0.550 | 0.324 |
 FEV1/FVC, % | 39.6 ± 12.8 | 39.6 ± 12.5 | 39.6 ± 12.5 | 40.2 ± 11.0 | 40.3 ± 11.2 | 40.4 ± 11.6 | 0.840 | 0.833 |
 Delta IC, L | −0.22 ± 0.18 | −0.18 ± 0.16 | −0.16 ± 0.15*a | −0.18 ± 0.17 | −0.13 ± 0.12*a | −0.09 ± 0.13**a | 0.146 | 0.099 |
6MWT | ||||||||
 6MWD, m | 128.5 ± 85.6 | 191.4 ± 89.3 | 245.5 ± 103.1**a,b | 178.9 ± 81.6 | 260.1 ± 87.7**a | 304.6 ± 84.4**a,b | 0.014c | 0.044c |
 SpO2, % pre 6MWT | 94.4 ± 3.4 | 95.0 ± 3.1 | 95.5 ± 2.6*a | 93.8 ± 2.5 | 95.1 ± 2.4*a | 95.6 ± 2.1**a | 0.957 | 0.802 |
 SpO2, % post 6MWT | 87.4 ± 4.2 | 88.9 ± 4.9*a | 90.5 ± 2.8**a,b | 88.9 ± 4.4 | 90.7 ± 3.1**a | 91.8 ± 2.4**a | 0.136 | 0.103 |
 HR, pre 6MWT | 98.4 ± 10.7 | 92.1 ± 11.3**a | 91.7 ± 10.8**a | 96.5 ± 11.5 | 92.6 ± 10.5**a | 91.3 ± 10.4**a | 0.880 | 0.899 |
 HR, post 6MWT | 125.6 ± 8.1 | 124.4 ± 7.8 | 125.1 ± 7.4 | 125.6 ± 14.0 | 122.7 ± 6.4 | 122.0 ± 6.6 | 0.426 | 0.141 |
Laboratory data | ||||||||
 WBCs, 103/μl | 14.80 ± 5.22 | 8.73 ± 2.01**a | 7.92 ± 1.56**a | 14.71 ± 4.44 | 8.18 ± 2.65**a | 7.06 ± 1.51**a | 0.439 | 0.072 |
 CRP, mg/dl | 8.41 ± 6.77 | 1.73 ± 1.73**a | 0.30 ± 0.39**a | 5.11 ± 5.60 | 1.07 ± 1.57**a | 0.07 ± 0.12**a | 0.192 | 0.020c |
 pH | 7.36 ± 0.08 | 7.40 ± 0.04**a | 7.42 ± 0.05**a | 7.36 ± 0.08 | 7.41 ± 0.05*a | 7.42 ± 0.04**a | 0.479 | 0.949 |
 PaCO2, mmHg | 51.5 ± 24.1 | 45.1 ± 15.5*a | 45.1 ± 13.5*a | 52.6 ± 20.3 | 40.1 ± 5.5*a | 46.0 ± 17.0**a | 0.752 | 0.755 |
 PaO2, mmHg | 63.2 ± 15.3 | 82.9 ± 21.0**a | 81.9 ± 18.0**a | 66.1 ± 14.7 | 82.7 ± 16.8**a | 83.1 ± 17.3**a | 0.976 | 0.825 |
 HCO3− | 24.88 ± 4.24 | 25.04 ± 5.82*a | 27.35 ± 4.51*a,b | 26.26 ± 5.98 | 27.15 ± 4.04 | 28.75 ± 4.15*a | 0.169 | 0.290 |