Table 1 Characteristics of the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in the high-flow nasal therapy pulmonary rehabilitation (HFNT PR) and non-HFNT PR groups
Characteristic | Non-HFNT PR (N = 22) | HFNT PR (N = 22) | p value |
|---|---|---|---|
Age, years | 73.1 ± 6.4 | 72.3 ± 7.7 | 0.703 |
Gender, M (%) | 15 (77.3) | 17 (77.3) | 0.728# |
Smoking status |  |  | < 0.001# |
 Non-smoker, n (%) | 1 (4) | 3 (13) |  |
 Current smoker, n (%) | 5 (22) | 0 (0) |  |
 Ex-smoker, n (%) | 16 (72) | 19 (86) |  |
Body-mass index, kg/m2 | 19.8 ± 3.1 | 20.3 ± 3.4 | 0.614 |
Pulmonary function test (PFT) | |||
 FVC, % predicted normal | 80.0 ± 27.8 | 74.3 ± 16.2 | 0.412 |
 FEV1, % predicted normal | 36.5 ± 10.3 | 36.6 ± 8.0 | 0.911 |
 FEV1/FVC, % | 39.6 ± 12.8 | 40.2 ± 11.0 | 0.851 |
 Delta IC, L | −0.22 ± 0.18 | −0.18 ± 0.17 | 0.513 |
6MWT | |||
 6MWD, m | 128.5 ± 85.6 | 177.0 ± 89.2 | 0.0524 |
 SpO2 pre/post 6MWT, % | 94.4/87.3 | 93.8/88.9 | 0.484/0.241 |
 HR pre/post 6MWT, % | 98.4/125.6 | 96.4/ 125.6 | 0.572/0.979 |
mMRC, score | 3.5 ± 0.5 | 3.1 ± 0.4 | 0.004 |
CAT score | 30.9 ± 2.1 | 28.9 ± 2.8 | 0.009 |
BODE score | 8.1 ± 1.3 | 7.1 ± 1.1 | 0.010 |
Laboratory | |||
 WBCs, 103/μl | 14.8 ± 5.2 | 14.7 ± 4.4 | 0.951 |
 CRP, mg/dl | 8.4 ± 6.8 | 5.1 ± 5.6 | 0.086 |
 pH | 7.36 ± 0.08 | 7.36 ± 0.08 | 0.973 |
 PaCO2, mmHg | 51.5 ± 24.1 | 52.6 ± 20.3 | 0.8691 |
 PaO2, mmHg | 63.2 ± 15.3 | 66.1 ± 14.7 | 0.513 |
 HCO3− | 24.9 ± 4.2 | 26.3 ± 6.0 | 0.386 |
AE hospitalization in the previous PR 1 year, time | 2.6 ± 0.8 | 2.3 ± 0.7 | 0.167 |
Comorbidity | |||
 CVD, n (%) | 15 (68) | 16 (72) | 0.741# |
 GERD, n (%) | 6 (27) | 9 (40) | 0.340# |
 Osteoporosis, n (%) | 7 (31) | 5 (22) | 0.498# |
 Diabetes, n (%) | 6 (27) | 5 (22) | 0.728# |
 Chronic renal failure, n (%) | 2 (9) | 3 (13) | 0.635# |
 Anxiety, n (%) | 4 (18) | 3 (13) | 0.680# |
Length of hospitalization, days | 8.6 ± 1.3 | 8.3 ± 1.9 | 0.459 |