Standardofcare event rate*

Antimicrobial therapy strategy event rate*

Oneyear Event Rate Reduction

Power


24%

16.8%

30%

78%

30%

21.0%

30%

87%

36%

25.2%

30%

93%

24%

16.0%

33.3%

86%

30%

20.0%

33.3%

93%

36%

24.0%

33.3%

97%

24%

15.6%

35%

89%

30%

19.5%

35%

95%

36%

23.4%

35%

98%

 *12month event rates. Calculations assume a 2sided TypeI error rate of 0.05. The minimum followup is planned to be 12 months and the maximum followup is 42 months. Dropout rates are assumed to be approximately 2% per year. Power calculations were based on a logrank test with assumed event rates were exponentially distributed. Calculations were computing using nQuery 7.0 software