Skip to main content

Advertisement

Table 3 Doxycycline study - comparisons of enrollment and follow-up assessments*

From: Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial

Endpoint N Enrollment
Mean (SD)
Follow-up
Mean (SD)
Paired T-test
p-value
Body Mass Index (kg/m2) 6 25.41 (4.41) 26.07 (4.45) 0.080
6 Minute Walk Test (feet) 5 1142 (159) 1283 (194) 0.110
St. George’s Respiratory Questionnaire – total score 6 50.90 (8.38) 18.40 (6.39) 0.002
FVC percent predicted (%) 6 61.38 (10.65) 67.67 (14.39) 0.311
MMP9 activity 6 6.19 (2.04) 2.59 (0.66) 0.006
MMP3 activity 6 9.03 (2.02) 4.83 (3.54) 0.041
MMP9 expression 6 3.39 (1.06) 1.45 (0.41) 0.004
TIMP-1 expression 6 5.28 (1.56) 2.72 (0.67) 0.018
VEGF expression 6 9.03 (2.02) 4.83 (3.54) 0.041
  1. *Data are taken from [15]. Activities levels are determined from Western Blot. See [15] for more details