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Table 1 Effect of melatonin and ramelteon on oxygenation

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Treatment group

PaO2

Control

120.3 ± 8.8

Control + melatonin

117.5 ± 10.3

Control + Ramelteon

117.1 ± 22.5

Control + luzindole

115.8 ± 14.5

VILI

65.6 ± 20.6*

VILI+ luzindole

64.7 ± 24.3*

VILI+ Melatonin

116.7 ± 21.0#

VILI + Melatonin + luzindole

80.4 ± 13.7*

VILI + Ramelteon

105.7 ± 22.3#

VILI + Ramelteon + luzindole

79.8 ± 13.9*

  1. The data are expressed as the mean ± SD. *Significantly different from the control (P < 0.05); # Significantly different from the VILI group (P < 0.05)