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Table 1 Effect of melatonin and ramelteon on oxygenation

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Treatment groupPaO2
Control120.3 ± 8.8
Control + melatonin117.5 ± 10.3
Control + Ramelteon117.1 ± 22.5
Control + luzindole115.8 ± 14.5
VILI65.6 ± 20.6*
VILI+ luzindole64.7 ± 24.3*
VILI+ Melatonin116.7 ± 21.0#
VILI + Melatonin + luzindole80.4 ± 13.7*
VILI + Ramelteon105.7 ± 22.3#
VILI + Ramelteon + luzindole79.8 ± 13.9*
  1. The data are expressed as the mean ± SD. *Significantly different from the control (P < 0.05); # Significantly different from the VILI group (P < 0.05)