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Fig. 9 | Respiratory Research

Fig. 9

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 9

Effect of an anti-IL-10 antibody on melatonin- and ramelteon-mediated BALF IL-10 levels. VILI significantly decreased IL-10 levels in BALF. Melatonin or ramelteon treatment significantly reversed this phenomenon. When an anti-IL-10 antibody was administered, the protective effect of melatonin and ramelteon was blocked. Data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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