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Fig. 8 | Respiratory Research

Fig. 8

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 8

Effect of melatonin and ramelteon on apoptosis. Hsp70 (a), Bcl-2 (b), caspase-3 (c), and cleaved PARP (d) levels in the lung tissue were determined by western blotting. Melatonin or ramelteon treatment increased Hsp70 and Bcl-2 levels and reduced caspase-3 and cleaved PARP levels in VILI. When luzindole was added, the protective effect was blocked. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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