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Fig. 7 | Respiratory Research

Fig. 7

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 7

Effect of melatonin and ramelteon on the NF-κB signaling pathway. a The NF-κB p65 level and b IκBα level in the lung tissue were determined by western blotting. PCNA and β-actin served as loading controls for nuclear and cytoplasmic proteins, respectively. Representative blots are shown. Melatonin or ramelteon treatment reduced NF-κB p65 levels and increased IκB-α levels in VILI. When luzindole was added, the protective effect was blocked. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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