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Fig. 5 | Respiratory Research

Fig. 5

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 5

Effect of melatonin and ramelteon on iNOS expression. iNOS levels in the lung tissue were determined by western blotting. β-Actin served as a loading control for cytoplasmic proteins. VILI significantly increased iNOS protein expression. Melatonin or ramelteon treatment significantly attenuated the increase. When luzindole was added, the protective effect of melatonin and ramelteon was blocked. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p-values < 0.05); # significantly different from the VILI group (p < 0.05)

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