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Fig. 2 | Respiratory Research

Fig. 2

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 2

Effect of melatonin and ramelteon on serum malondialdehyde (MDA) levels, carbonyl content and myeloperoxidase (MPO)-positive cell numbers in lung tissue. Serum MDA levels (a), carbonyl content (b) and MPO-positive cell numbers in lung tissue (c) were significantly increased in the VILI group. Melatonin or ramelteon treatment significantly attenuated these increases. The protective effect of melatonin and ramelteon was abrogated by luzindole treatment. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p-values < 0.05); #significantly different from the VILI group (p < 0.05)

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