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Fig. 13 | Respiratory Research

Fig. 13

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 13

Effect of an anti-IL-10 antibody on the melatonin- and ramelteon-mediated apoptosis and NF-κB signaling pathway. a Bcl2, b cleaved PARP,and c NF-κB p65 levels in the lung tissue were determined by western blotting. Lamin B and β-actin served as loading controls for nuclear and cytoplasmic proteins, respectively. Melatonin or ramelteon treatment increased Bcl2, and reduced cleaved PARP and NF-κB p65 levels in VILI. When anti-IL-10 antibody was added, the protective effect was blocked. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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