Skip to main content


Fig. 12 | Respiratory Research

Fig. 12

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 12

Effect of an anti-IL-10 antibody on the melatonin- and ramelteon-mediated lung pathology. a Hematoxylin and eosin staining analysis of lung pathological injury. b The numbers of neutrophils per high-power field, and c lung injury score. Representative photomicrographs were taken at a magnification of × 400. Histological evaluation of lung tissues showed that neutrophil infiltration and the lung injury score were increased in the VILI group. Melatonin or ramelteon treatment significantly attenuated these histopathological changes, but the protective effect of melatonin and ramelteon was abrogated by anti-IL-10 antibody treatment. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

Back to article page