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Fig. 11 | Respiratory Research

Fig. 11

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 11

Effect of an anti-IL-10 antibody on the melatonin- and ramelteon-mediated cytokines concentrations in BALF. TNF-α (a), IL-1β (b), and IL-6 (c) levels in BALF increased significantly in the VILI group. The increases in the BALF protein concentrations were significantly attenuated by treatment with melatonin or ramelteon. The protective effect of melatonin and ramelteon was abrogated by anti-IL-10 antibody treatment. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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