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Fig. 6 | Respiratory Research

Fig. 6

From: Evaluation of secondhand smoke effects on CFTR function in vivo

Fig. 6

Oral administration of N-acetylcysteine (NAC) prevents loss of CFTR-mediated ion transport in mice exposed to secondhand smoke (SHS).a. Representative nasal potential difference (NPD) tracing for CFTR-dependent epithelial ion transport in mice that were exposed to either control room air or SHS for 6 weeks with or without NAC added to drinking water (40 mM). b. Summary graphs illustrate changes in total CFTR-dependent voltage following infusion of chloride-free ringers and forskolin (10 μM) across nasal epithelium. Reductions in CFTR activity are separately described for the fraction of channels that were open at baseline and responded to chloride-free ringers (c) and the closed fraction that were activated by addition of forskolin (d). n = 7–19, *P < 0.05, **P < 0.005

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