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Fig. 2 | Respiratory Research

Fig. 2

From: Evaluation of secondhand smoke effects on CFTR function in vivo

Fig. 2

Secondhand smoke (SHS) exposure decreases CFTR-mediated chloride ion transport in vivo. a. Representative nasal potential difference (NPD) tracings acquired in mice exposed to control room air as a control or SHS for 6 weeks using a custom-built nose-only inhalation exposure system. b. Summary graph illustrates changes in total CFTR-dependent voltage following sequential infusion of chloride-free ringers and forskolin (10 μM). Reductions in CFTR activity are shown for the proportion of CFTR channels that were open at baseline and responded to chloride-free ringers alone (c) and separately for those that were closed until activation by forskolin (d). e. Differences in CFTR activity are represented following addition of CFTR-specific inhibitor CFTRinh172. n = 6–8, *P < 0.05; **P < 0.005

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