Skip to main content

Advertisement

Table 3 Patient-reported outcomes (SF-12, MRC scale, and 6 MWD)

From: Effect of average volume-assured pressure support treatment on health-related quality of life in COPD patients with chronic hypercapnic respiratory failure: a randomized trial

VariablesPatients treated with AVAPSControl groupTreatment Effect (95% CI)
6 months–baseline
P-Value
BaselineAfter 6 monthBaselineAfter 6 month
SF-36 Scales #
 Vitality55.2 ± 16.164.3 ± 17.556.1 ± 17.360.5 ± 16.25.4(1.4 to 9.3)0.001*
 General health56.3 ± 20.561.3 ± 16.757.6 ± 19.258.4 ± 20.28.2(3.2 to 11.7)0.001*
 Physical functioning72.4 ± 23.877.5 ± 21.569.3 ± 24.269.6 ± 22.15.5(1.1 to 9.8)0.001*
 Bodily pain62.3 ± 23.265.5 ± 22.463.7 ± 23.666.7 ± 20.83.1 (3.4 to 8.80.002*
 Emotional Role Functioning80.6 ± 22.583.5 ± 24.779.0 ± 24.882.3 ± 20.7−0.5 (−6.8 to 5.3)0.321
 Physical Role Functioning69.3 ± 23.373.5 ± 26.670.8 ± 23.773.2 ± 24.83.3(−5 to 6.6)0.001*
 Social Role Functioning79.6 ± 23.883.6 ± 24.780.8 ± 21.982.9 ± 25.81.6 (−3.8 to 6.4)0.143
 Mental health74.4 ± 18.675.8 ± 12.875.6 ± 15.775.4 ± 15.41.2 (−1.7 to 6.9)0.543
 PCSS45.3 ± 9.651.3 ± 8.444.1 ± 8.444.7 ± 7.23.7 (1.2 to 5.8)0.001*
 MCSS50.3 ± 10.853.5 ± 12.749.2 ± 11.852.7 ± 11.21.1 (−2.7 to 2.9)0.436
 MRC scale #4.3 ± 0.53.1 ± 0.24.1 ± 0.74 ± 0.40.4(−0.2 to 3)0.213
 6MWD, m #178.2 ± 24.3260.5 ± 32.2179.3 ± 32.1255.2 ± 30.29.2(−1 to 15)0.001*
  1. Data presented as mean (standard deviation); #: The SF-12, MRC scores, and 6MWD were skewed distributed; therefore a Mann-Whitney U test was performed to compare the changes within the groups; the delta scores were normally distributed, therefore the changes were compared with a regression analysis. A positive mean difference means a decrease or an increase from baseline to 6 months for the S/T AVAPS compared to S/T BiPAP (control)
  2. Abbreviations: SF-12 Short Form 12 Health Survey Questionnaire CI confidence interval PCSS physical component summary score MCSS mental component summary score, MRC Medical Research Council 6MWD 6-min walking distance