Table 1 Differentially expressed genes
From: Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
Exclusively upregulated genes | Symbol |
|---|---|
Upregulated exclusively by ECIG compared to Ctr > 1.30 (range depicted 1.37–1.31, descending order) | CYP2A6, ZNF286A, APOBEC3B, WDR57, LPCAT2, LYPD2, CYP2B7P1, SLCO2A1 |
Upregulated exclusively by TCIG compared to ECIG > 1.30 (range depicted 1.52–1.33, descending order) | ARHGEF16, GDF15, PRDM1, RINT1, NTHL1, CYB5R2, CYP4F12, TNFRSF10A, RGS19, EDC3, APN5, SLC35C1, OTUB2, B3GNT8, ULK3, KRT18P17, CDC37L1, MAFF, CYP4F22, EHBP1L1 |
Upregulated exclusively by TCIG compared to Ctr > 1.30 (range depicted 1.56–1.45, descending order) | MAOB, IGSF5, CEP55, SPRED2, CICE, FKBP4, NIT2, MTHFS, NAPG, GDPD3, FEZ1, IFRD2, FOSL1, SHISA2, MVD, WDR72, AMN1, CYBASC3, GATC, IL1F5 |
Exclusively downregulated genes | |
Downregulated exclusively by ECIG compared to Ctr < 0.60 (range depicted 0.56–0.59, increasing order) | C14orf85, NBPF8, CYP3A5, SNORA61, FLJ36131 |
Downregulated exclusively by TCIG compared to ECIG < 0.60 (range depicted 0.45–0.58, increasing order) | CYP2A6, SLCO2A1, HSPB3, TPM1, LYPD2, CA9, ALOX5AP, RTDR1, APCDD1, CYP4X1, C13orf30, SCARA3, MGC39900, RSPH9, MYLK, NGB, PPM1E, DNAI1, PTPRZ1, TSPAN8 |
Downregulated exclusively by TCIG compared to Ctr < 0.60 (range depicted 0.49–0.58 increasing order) | RYR3, DNAH12L, ODZ3, S100A3, AHNAK2, MIR221, ENC1, SMA4, TNFAIP8L1, MIR21, FLJ44342, TTC18, MEX3B, RGMA, FLJ23834, MAFB, MMP13, DNHD2, C1orf63, DCBLD1 |
Commonly deregulated genes | |
Upregulated commonly in TCIG/ECIG and TCIG/Ctr > 1.30 (range depicted 37.5–2.50, descending order) | CYP1A1, ANXA10, S100A12,PANX2, SLC7A11, CLDN10, UGT1A6, AKR1B15, C9orf169, GPX2, UCHL1, HSD17B2, IL1B, TRIB3, SLC7A5, ZBED2, CYP1B1, ENPEP, S100A7, PRSS3 |
Upregulated commonly in ECIG/Ctr and TCIG/Ctr > 1.30 (range depicted 1.37–1.31, descending order) | (LOC100128899, LOC391019) |
Downregulated commonly in TCIG/ECIG and TCIG/Ctr < 0.60 (range depicted 0.29–0.42, increasing order) | C6orf205, MUC21, TNC, CYP4B1, PPARGC1A, EDN1, TAGLN, LOX, CYP2F1, CALML3, ERP27, MMP10, CDH2, MXRA5, EGFL6, COL4A1, ATP12A, CDH11, UBD, CILP |
Downregulated commonly in TCIG/Ctr and ECIG/Ctr < 0.60 (range depicted 0.51–0.59, increasing order) | FAM175A, MIR205, CATSPER2, GABRE, MGC16121 |