Skip to main content

Table 2 Hemodynamic and cardiac functional parameters according to the BMPR2 mutations of pulmonary hypertension

From: Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis

VariablesMutationsNon-mutationsMD/OR(95%CI)P value
Age at diagnosis (yrs)35.12 ± 12.79 (556)40.17 ± 16.25 (1174)−3.70 [−6.52, −0.87]<0.00001
6MWD (m)363.12 ± 113.97 (332)369.22 ± 116.82 (863)−14.81 [−45.24, 15.62]0.34
mPAP (mmHg)61.21 ± 12.73 (570)56.37 ± 14.08 (1197)4.82 [2.38, 7.25]0.0001
PVR (Wood units)18.65 ± 8.69 (557)15.11 ± 7.8 (1166)3.90 [3.23, 4.57]<0.000
CI (L/ml/m2)2.08 ± 0.65 (547)2.51 ± 0.86 (1156)−0.44 [−0.63, − 0.24]<0.000
RVP (mmHg)8.30 ± 4.99 (405)7.41 ± 5.60, 835 (835)−0.32 [− 0.91, 0.27]0.29
NYHA III67.95% (312)70.22% (648)0.84 [0.62, 1.14]0.26
NYHA IV11.54% (312)6.94% (648)1.71 [1.07, 2.72]0.02
  1. 6MWD 6 min walk distance, mPAP mean PAP, PVR pulmonary vascular resistance, CI cardiac index, RVP right ventricular pressure; these results are expressed as mean ± SD. NYHA new york heart association functional classification, expressed as % (patients number); MD mean difference, OR odd ratio, 95% CI 95% confidence interval