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Table 3 Baseline characteristics of patients included in the INPULSIS® pooled data set, experiencing no acute exacerbations or experiencing ≥ 1 acute exacerbation (analysis 2)

From: Health-related quality of life and symptoms in patients with IPF treated with nintedanib: analyses of patient-reported outcomes from the INPULSIS® trials

 

No acute exacerbations (n = 998)

≥ 1 acute exacerbation (n = 63)

Women, n (%)

209 (20.9)

11 (17.5)

Age, years

66.6 (8.0)

69.3 (7.5)

Time since IPF diagnosis, years

1.6 (1.3)

1.8 (1.4)

Ethnicity, n (%)

 White

578 (57.9)

30 (47.6)

 Black

2 (0.2)

0 (0)

 Asian

304 (30.5)

18 (28.6)

 Missing

114 (11.4)

15 (23.8)

BMI, kg/m2

28.0 (4.6)

27.1 (4.1)

Smoking history, n (%)

 Non-smoker

281 (28.2)

15 (23.8)

 Ex-smoker

670 (67.1)

48 (76.2)

 Current smoker

47 (4.7)

0 (0)

Comorbidities, n (%)

 PH

30 (3.0)

0 (0)

 COPD

25 (2.5)

2 (3.2)

 Lung cancera

4 (0.4)

0 (0)

 GERD

231 (23.1)

17 (27.0)

 CAD

85 (8.5)

3 (4.8)

FVC, % predicted

80.2 (17.8)

69.4 (15.0)

FEV1/FVC ratio

81.5 (5.9)

84.2 (5.5)

DLCO, % predicted

47.5 (13.3)

42.6 (15.2)

  1. Data are shown in mean (standard deviation), unless otherwise indicated. aLung cancer includes malignant lung neoplasm, squamous cell carcinoma of lung, non-small-cell lung cancer and metastatic lung adenocarcinoma
  2. BMI body mass index, CAD coronary artery disease, COPD chronic obstructive pulmonary disease, DLCO diffusing capacity of the lungs for carbon monoxide, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, GERD gastroesophageal reflux disease, IPF idiopathic pulmonary fibrosis, PH pulmonary hypertension