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Table 1 Classification of subgroups defined by clinical and physiologic indicators of less-advanced disease or advanced disease at baseline

From: Health-related quality of life and symptoms in patients with IPF treated with nintedanib: analyses of patient-reported outcomes from the INPULSIS® trials

Clinical measureSubgroup with less-advanced diseaseSubgroup with advanced disease
GAP stageIII/III
% predicted FVC, %>  80≤ 80
% predicted DLCO, %>  40≤ 40
CPI≤ 45>  45
SGRQ total score≤ 40>  40
  1. CPI composite physiologic index, DLCO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, GAP gender, age and physiology, SGRQ St George’s respiratory questionnaire