Fig. 5

SMARCD1 nearest-neighbor adjacency subnetwork with the glucocorticoid receptor response pathway. The orange arrow originating from cortisol to SMARCD1 indicates that cortisol is a controller of SMARCD1. The blue directed edge from SMARCD1 to SGK1 (glucocorticoid regulated kinase 1) demonstrates the known relationship between SMARCD1 expression and increased expression of SGK1. The gray dotted lines indicate that SMARCD1 co-complexes with the connected node proteins, including Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), a glucocorticoid receptor