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Table 3 Univariate and multivariate Cox proportional hazard regression analysis for development of tuberculosis

From: The impact on incident tuberculosis by kidney function impairment status: analysis of severity relationship

Variables

HR

95% CI

P-value

Adjusted HR

95% CI

P-value

Age, years (ref: ≤ 40)

 40–55

1.581

1.227

2.037

0.0004

1.392

1.079

1.797

0.0109

 55–65

2.521

1.975

3.218

< 0.0001

2.040

1.592

2.614

< 0.0001

 > 65

6.240

5.018

7.758

< 0.0001

4.439

3.530

5.583

< 0.0001

Male (ref: female)

2.460

2.159

2.802

< 0.0001

2.258

1.977

2.578

< 0.0001

Kidney function

 CKD stage1 & 2

1

–

–

–

1

–

–

–

 CKD stage 3a

2.374

1.958

2.879

< 0.0001

1.215

0.995

1.484

0.0563

 CKD stage 3b

3.232

2.505

4.172

< 0.0001

1.538

1.182

2.002

0.0014

 CKD stage 4

4.263

3.065

5.930

< 0.0001

2.065

1.473

2.894

< 0.0001

 CKD stage 5

4.792

3.135

7.325

< 0.0001

2.877

1.872

4.421

< 0.0001

 Long-term dialysis

2.462

1.319

4.595

0.0046

2.041

1.092

3.815

0.0254

 Kidney transplant

20.311

5.090

81.050

< 0.0001

15.269

3.806

61.252

0.0001

COPD

4.271

3.147

5.797

< 0.0001

1.581

1.149

2.174

0.0049

Asthma

1.574

1.000

2.479

0.0501

    

Bronchiectasis

4.617

2.726

7.822

< 0.0001

2.959

1.717

5.098

< 0.0001

Pneumoconiosis

31.004

16.083

59.768

< 0.0001

10.149

5.191

19.845

< 0.0001

IPF

3.221

1.207

8.598

0.0195

1.423

0.522

3.882

0.4903

GERD

1.287

0.963

1.720

0.0876

    

Obesity

0.168

0.024

1.193

0.0745

    

Cancer

2.409

2.090

2.776

< 0.0001

2.006

1.735

2.319

< 0.0001

Cirrhosis

2.160

1.441

3.237

0.0002

1.275

0.847

1.920

0.2440

Congestive heart failure

3.124

2.268

4.302

< 0.0001

1.749

1.262

2.426

0.0008

Stroke

1.337

0.789

2.265

0.2806

    

Diabetes mellitus

1.929

1.647

2.259

< 0.0001

1.221

1.037

1.438

0.0166

SLE

3.311

2.022

5.423

< 0.0001

6.323

3.808

10.500

< 0.0001

RA

2.087

1.208

3.606

0.0084

2.305

1.318

4.034

0.0034

Dermatomyositis

2.213

0.312

15.681

0.4267

    

Transplant, othersa

2.107

0.790

5.622

0.1364

    
  1. Abbreviation: BMI Body mass index, CKD Chronic kidney disease, COPD Chronic obstructive pulmonary disease, eGFR Estimated glomerular filtration rate, GERD Gastroesophageal reflux disease, IPF Idiopathic pulmonary fibrosis, RA Rheumatoid arthritis, SLE Systemic lupus erythematosus
  2. aOther than kidney transplant
  3. The p value data in multivariate analysis are bold if < 0.05
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Respiratory Research

ISSN: 1465-993X

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