Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study

Table 2 Hierarchical stepwise linear regression considering FEV₁% variation as dependent variable and Nrf2, HO-1 and GCLC mRNA, plasma GSH, plasma 8-iso % variation and baseline smoking history (pack-year) as independent variables in COPD group (n.33)

Independent variable	Standardized Beta coefficients	P value	R²	Predicted R²
FEV₁% variation
Nr2 mRNA (% variation)	0.405	0.001
HO-1 mRNA (% variation)	0.364	0.006
GCLC mRNA (% variation)	0.322	0.015
plasma 8-iso (% variation)	0.096	0.315
plasma GSH (% variation)	0.074	0.403
pack-year	0.059	0.477
			0.895	0.881

ISSN: 1465-993X