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Table 4 Correlations between change in IC and selected respiratory and cardiac variables for BUD/FORM and placebo

From: Metabolic and cardiorespiratory effects of decreasing lung hyperinflation with budesonide/formoterol in COPD: a randomized, double-crossover, placebo-controlled, multicenter trial

Outcome, unit

Pearson correlation coefficient (vs IC)a

VO2, mL/min

0.067

HR, bpm

−0.079

VO2/HR, mL/beat

0.138

VCO2, mL/min

0.022

SaO2, %

0.115

FEV1, L

0.432

FVC, L

0.522

FEV1/FVC

0.126

VT, mL

0.191

VT/Ti, mL/sec

−0.016

Ti/Ttot

0.181

RR, breaths/min

−0.063

Ve (RR × VT), mL/min

0.158

MBS

−0.051

  1. bpm, beats per minute; BUD/FORM, budesonide/formoterol; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; HR, heart rate; IC, inspiratory capacity; MBS, Modified Borg Dyspnea Scale; RR, respiratory rate; SaO2, oxygen saturation; Ti/Ttot, respiratory time fraction; VCO2, carbon dioxide output; Ve, minute ventilation; VO2, oxygen uptake; VO2/HR, oxygen pulse; VT, tidal volume; VT/Ti, inspiratory flow rate
  2. aPearson correlation computed between the given efficacy endpoints (change from pre-dose to post-dose) for BUD/FORM and placebo across all visits