SUN (n = 989) | SHINE (n = 561) | US3 (n = 807) | RISE (n = 1219) | |||||
---|---|---|---|---|---|---|---|---|
BUD/FORM 160/4.5 μg bid (n = 494) | FORM 4.5 μg bid (n = 495) | BUD/FORM 160/4.5 μg bid (n = 277) | FORM 4.5 μg bid (n = 284) | BUD/FORM 160/4.5 μg bid (n = 404) | FORM 4.5 μg bid (n = 403) | BUD/FORM 160/4.5 μg bid (n = 606) | FORM 4.5 μg bid (n = 613) | |
Any CID | 343 (69.4) | 360 (72.7) | 173 (62.5) | 196 (69.0) | 280 (69.3) | 305 (75.7) | 468 (77.2) | 517 (84.3) |
Subtypes of first CID | ||||||||
Exacerbation alone | 81 (23.6) | 96 (26.7) | 47 (27.2) | 47 (24.0) | 114 (40.7) | 126 (41.3) | 61 (13.0) | 74 (14.3) |
FEV1 event alone | 120 (35.0) | 112 (31.1) | 62 (35.8) | 59 (30.1) | 90 (32.1) | 86 (28.2) | 172 (36.8) | 174 (33.7) |
SGRQ alone | 116 (33.8) | 112 (31.1) | 49 (28.3) | 76 (38.8) | 61 (21.8) | 75 (24.6) | 172 (36.8) | 171 (33.1) |
Exacerbation + FEV1 | 3 (0.9) | 5 (1.4) | 0 (0.0) | 2 (1.0) | 6 (2.1) | 8 (2.6) | 5 (1.1) | 7 (1.4) |
Exacerbation + SGRQ | 3 (0.9) | 4 (1.1) | 4 (2.3) | 2 (1.0) | 1 (0.4) | 4 (1.3) | 6 (1.3) | 7 (1.4) |
FEV1 + SGRQ | 20 (5.8) | 30 (8.3) | 10 (5.8) | 10 (5.1) | 7 (2.5) | 5 (1.6) | 51 (10.9) | 79 (15.3) |
Exacerbation + FEV1 + SGRQ | 0 (0) | 1 (0.3) | 1 (0.6) | 0 (0) | 1 (0.4) | 1 (0.3) | 1 (0.2) | 5 (1.0) |
Individual components | ||||||||
Exacerbations | 152 (30.8) | 177 (35.8) | 69 (24.9) | 78 (27.5) | 169 (41.8) | 182 (45.2) | 151 (24.9) | 181 (29.5) |
FEV1 events | 196 (39.7) | 212 (42.8) | 84 (30.3) | 100 (35.2) | 135 (33.4) | 161 (40.0) | 289 (47.7) | 344 (56.1) |
SGRQ events | 188 (38.1) | 202 (40.8) | 81 (29.2) | 116 (40.8) | 143 (35.4) | 164 (40.7) | 312 (51.5) | 357 (58.2) |