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Fig. 5 | Respiratory Research

Fig. 5

From: Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls

Fig. 5

Azithromycin induces lysosomal accumulation in control and IPF fibroblasts. a Control (A1–3) and IPF fibroblasts (A4–6) were treated with AZT for 24 h, fixed and analyzed by electron microscopy. (A1, 4) Overview, (A2, 5) late endosomes or lysosomes (arrows), (A3, 6) autolysosomes, double membrane (arrows). b Lysotracker green staining in control (upper images, n = 3) and IPF fibroblasts (lower images, n = 3) after 24 h treatment with AZT in presence or absence of TGF-β confirmed the vacuolar structures as lysosomes. Magnification of 63x. Scale bar = 10 μM. All experiments were performed in three independent experiments

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Respiratory Research

ISSN: 1465-993X

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