Downregulation of hsa-microRNA-204-5p and identification of its potential regulatory network in non-small cell lung cancer: RT-qPCR, bioinformatic- and meta-analyses

Table 6 Diagnostic accuracy evaluation of miR-204-5p by ROC analysis. Annotation: AUC, area under the receiver operating characteristic curve; 95% CI, 95% confidence interval; LL, lower limit; UL, upper limit; Q, heterogeneity Q test; P_het, P value of heterogeneity. LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma

Sample type	Study number	Enrolled number	AUC	Overall estimate			Heterogeneity			Pretest probability
Sample type	Study number	Enrolled number	AUC	95% CI (LL-UL)	sensitivity	specificity	Q	I² (%)	P_het	Pretest probability
Overall	31	4368	0.74	0.70–0.77	0.76	0.58	864.488	99.77	0.000	0.686
Tissue	20	3534	0.75	0.71–0.78	0.65	0.74	328.601	99.39	0.000	0.722
Plasma	11	834	0.70	0.66–0.74	0.90	0.27	279.536	99.28	0.000	0.535
LUAD	7	1269	0.78	0.74–0.81	0.63	0.78	150.286	98.67	0.000	0.742
LUSC	4	1001	0.66	0.62–0.70	0.32	0.90	3.112	35.72	0.106	0.748
LUAD-tissue	5	1211	0.79	0.75–0.82	0.61	0.81	106.761	98.13	0.000	0.752