Table 5 Information and ROC fourfold table for all datasets. Annotation: No, number of NSCLC cases and the matched group, respectively; AUC, area under the receiver operating characteristic curve; TPtrue positive, FNfalse negative, FPfalse positive, TNtrue negative. Since no citations were reflected for GSE16512, GSE17681, GSE24709, GSE46729, GSE93300, GSE19945 and GSE74190, websites were the alternatives

GSE16512

Lodes MJ

2009

USA

plasma

[31]

3/14

0.536

−0.133

0.667

0.643

2

5

1

9

GSE17681

Keller A

2009

Germany

plasma

[32]

17/19

0.562

4.346

0.941

0.316

16

13

1

6

GSE24709

Keller A

2011

Germany

plasma

[33]

28/19

0.348

6.960

0.964

0.000

27

19

1

0

GSE27486

Patnaik SK

2010

USA

plasma

[34]

22/23

0.360

−0.025

0.045

0.957

1

1

21

22

GSE31568

Keller A

2011

Germany

plasma

[35]

32/70

0.409

5.016

0.875

0.816

28

57

4

13

GSE40738

Patnaik SK

2012

USA

plasma

[36]

86/59

0.582

−0.085

0.953

0.237

82

45

4

14

GSE46729

Godrey A

2014

USA

plasma

[37]

24/24

0.434

4.193

0.417

0.667

10

8

14

16

GSE61741

Keller A

2014

Germany

plasma

[38]

73/94

0.346

6.828

1.000

0.011

73

93

0

1

GSE68951

Leidinger P

2015

Germany

plasma

[39]

26/12

0.212

3.575

0.923

0.083

24

11

2

1

PMID:26497897

Guo W

2015

China

plasma

[15]

126/50

0.809

0.023

0.760

0.820

96

9

30

41

GSE93300

Liu X

2017

China

plasma

[40]

9/4

0.056

−3.499

1.000

0.000

9

4

0

0

GSE2564

Lu J

2005

USA

tissue

[41]

14/4

0.741

5.835

0.786

0.750

11

1

3

3

GSE14936

Seike M

2009

USA

tissue

[42]

26/26

0.607

8.545

0.500

0.731

13

7

13

19

GSE15008

Tan X

2009

China

tissue

[43]

187/174

0.447

7.941

0.294

0.776

55

39

132

135

GSE16025

Raponi M

2009

USA

tissue

[44]

61/10

0.454

4.813

0.131

1.000

8

0

53

10

GSE18692

Puissegur M

2009

France

tissue

[45]

13/13

0.917

−0.076

0.846

0.923

11

1

2

12

GSE19945

Ohba T

2010

Japan

tissue

[46]

20/8

0.769

−0.342

0.700

0.875

14

1

6

7

GSE25508

Guled M

2011

Finland

tissue

[47]

26/26

0.348

9.004

1.000

0.000

26

26

0

0

GSE29248

Ma L

2010

China

tissue

[48]

6/6

0.583

10.704

0.833

0.500

5

3

1

3

GSE36681

Jang JS

2012

USA

tissue

[49]

103/103

0.619

10.847

0.845

0.417

87

60

16

43

GSE47525

van Jaarsveld MT

2013

Netherlands

tissue

[50]

18/14

0.661

2.755

0.389

0.929

7

1

11

13

GSE48414

Bjaanaes MM

2014

Norway

tissue

[51]

154/20

0.900

1.503

0.825

0.900

127

2

27

18

GSE51853

Arima C

2014

Japan

tissue

[52]

126/5

0.821

−4.558

0.659

1.000

83

0

43

5

GSE53882

Pu HY

2014

China

tissue

[53]

397/151

0.521

0.965

0.554

0.589

220

62

177

89

GSE56036

Fujita Y

2014

Japan

tissue

[54]

14/27

0.574

3.960

0.929

0.333

13

18

1

9

GSE63805

Robles AI

2014

USA

tissue

[55]

32/30

0.468

1.443

0.250

0.933

8

2

24

28

GSE72526

Gasparini P

2015

Switzerland

tissue

[56]

67/18

0.786

1.793

0.731

0.833

49

3

18

15

GSE74190

Jin Y

2015

China

tissue

[57]

72/44

0.620

0.472

0.583

0.705

42

13

30

31

GSE102286

Mitchell KA

2017

USA

tissue

[58]

91/88

0.503

−0.529

0.714

0.443

65

49

26

39

TCGA

NR

NR

NR

tissue

NR

999/91

0.671

1.657

0.520

0.901

519

9

480

82

Current study

NR

NR

China

tissue

NR

125/125

0.613

2.350

0.320

0.864

40

17

85

108