Gene expression pattern analysis using dual-color RT-MLPA and integrative genome-wide association studies of eQTL for tuberculosis suscepitibility

Table 2 Analysis of differential expression of whole blood mRNA in ATB and LTBI patients by dcRT-MLPA method

mRNA	ATB	LTBI	P value	mRNA	ATB	LTBI	P value	mRNA	ATB	LTBI	P value
Il4	5.52	6.73	< 0.0001	Sec14l	2.859	3.2	0.0592	Timp2	8.155	8.266	0.5858
Il7r	9.15	8.147	< 0.0001	ltf	7.125	6.53	0.0761	Casp8	12.26	12.36	0.6134
Il8	9.254	9.844	< 0.0001	Mmp9	6.34	6.155	0.0969	Tnfrsf1a	12.04	12.01	0.7111
Tnfrsf1b	9.93	10.42	0.0001	Ccr7	13.02	12.93	0.1686	Ifng	9.85	9.82	0.717
Pgm5	9.11	7.982	0.0016	Bcl2	3.825	4.19	0.2555	Tgfb1	12.68	12.68	0.7831
Ccl19	9.28	8.435	0.0034	Cd4	5.815	5.71	0.3819	Cd8a	8.735	8.66	0.8726
Il2ra	7.445	7.784	0.0143	Il6	4.472	4.1	0.4205	Foxp3	11.04	10.96	0.8905
Marco	5.98	5.44	0.0174	Tnfrsf10c	10.38	10.48	0.4313	Blr1	6.32	6.336	0.9785
Fpr1	4.47	4.178	0.0206	Fcgr1a	5.03	5.041	0.4422	Cxcl10	10.41	10.37	0.9953

The 9 mRNAs in the first column showed significant differences in expression levels between the ATB and LTBI groups. Among them, il7r, pgm5, ccl19, marco, and fpr1 were up-regulated in ATB patients. Il4, il8, tnfrsf1b, and il2ra were up-regulated in LTBI patients
ATB active tuberculosis, LTBI latent tuberculosis infection

ISSN: 1465-993X