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Table 3 Correlation between percentage of IL-4-expressing Th2 cells, and demographic characteristics and key features of COPD

From: The elastin peptide VGVAPG increases CD4+ T-cell IL-4 production in patients with chronic obstructive pulmonary disease

 

Intracellular IL-4

Secreted IL-4

Age (years)a

p = 0.57

p = 0.49

 

r = − 0.11

r = 0.14

Sex (male/female)b

p = 0.42

p = 0.68

Smoking (pack years)a

p = 0.95

r = 0.32

 

r = 0.01

r = 0.20

Smoking (ex-smokers vs current-smokers)b

p = 0.70

p = 0.06

Chronic bronchitis (yes/no)b

p = 0.25

p = 0.16

Dyspnea scale (mMRC)a

p = 0.83

p = 0.18

 

r = 0.04

r = − 0.26

FEV1 (%)a

p = 0.66

p = 0.19

 

r = − 0.08

r = − 0.25

FVC (%)a

p = 0.76

p = 0.34

 

r = 0.06

r = − 0.19

FEV1/FVC (%)a

p = 0.25

p = 0.51

 

r = − 0.21

r = − 0.13

RV (%)a

p = 0.07

p = 0.71

 

r = 0.32

r = 0.07

TCL (%)a

p = 0.11

p = 0.53

 

r = 0.30

r = 0.02

RV/TCL (%)a

p = 0.56

p = 0.49

 

r = 0.11

r = 0.02

Emphysema (yes/no)b

p = 0.44

p = 0.88

Emphysema scorea

p = 0.40

p = 0.48

 

r = 0.16

r = 0.14

Eosinophils (%)a

p = 0.14

p = 0.17

 

r = − 0.28

r = 0.26

Eosinophils (total count)a

p = 0.52

p = 0.71

 

r = − 0.12

r = 0.07

Exacerbations (n per year)a

p = 0.82

p = 0.46

 

r = 0.04

r = − 0.15

ICS (yes/no)b

p = 0.27

p = 0.50

  1. mMRC modified Medical Research Council, FEV1 forced expiratory volume in one second, FVC forced vital capacity, RV residual volume, ICS inhaled corticosteroid
  2. aQuantitative data were evaluated by Spearman correlation test (p and r values)
  3. bQualitative data were evaluated by Mann and Whitney test (p values only)