Mutation profile of non-small cell lung cancer revealed by next generation sequencing

Respiratory Research

Table 3 Correlation of EGFR, PIK3CA, KRAS, TP53, and CTNNB1 mutations with clinicopathological features

Features		EGFR mutation			p-value	PIK3CA mutation			p-value	KRAS mutation			p-value	TP53 mutation			p-value	CTNNB1 mutation			p-value
		No	Yes	Total		No	Yes	Total		No	Yes	Total		No	Yes	Total		No	Yes	Total
Gender	Male	27	12	39	0.305	38	1	39	0.327	36	3	39	0.620	27	12	39	0.219	39	0	39	0.091
	Female	19	14	33		30	3	33		32	1	33		27	6	33		30	3	33
Age	< 62	24	12	36	0.624	33	3	36	0.303	33	3	36	0.303	25	11	36	0.276	35	1	36	1.000
	≥ 62	22	14	36		35	1	36		35	1	36		29	7	36		34	2	36
Stage	I–II	30	20	50	0.859	48	2	50	1.000	47	3	50	1.000	36	14	50	0.461	48	2	50	1.000
	III–IV	10	6	16		15	1	16		15	1	16		13	3	16		15	1	16
Histology type	ADC	36	25	61	0.059	60	1	61	0.008	57	4	61	1.000	48	13	61	0.053	58	3	61	1.000
	SqCC	9	1	10		7	3	10		10	0	10		5	5	10		10	0	10
Smoking status	Non-smokers	26	21	47	0.038	44	3	47	1.000	46	1	47	0.117	39	8	47	0.032	44	3	47	0.547
	Smokers	20	5	25		24	1	25		22	3	25		15	10	25		25	0	25

ISSN: 1465-993X