Table 2 Summary of correlations between SARS-CoV-2 entry-related gene expression and asthma-associated gene signatures
From: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
| Â | Asthma-associated gene signature | |||||
|---|---|---|---|---|---|---|
| Â | IL13 Th2 | Eosinophils | Th17 | Neutrophil | IL-6-TS | Inflammasome |
Sputum, n = 120 |  |  |  |  |  |  |
ACE2 | r = 0.38*** | r = 0.18* | r = − 0.23* | r = 0.02 | r = 0.14 | r = 0.07 |
TMPRSS2 | r = 0.57*** | r = 0.15 | r = − 0.06 | r = 0.03 | r = 0.02 | r = 0.10 |
FURIN | r = 0.10 | r = 0.13 | r = − 0.16 | r = 0.51*** | r = 0.54*** | r = 0.49*** |
Bronchial brushing, n = 149 |  |  |  |  |  |  |
ACE2 | r = 0.12 | r = − 0.07 | r = − 0.11 | r = 0.0005 | r = 0.11 | r = 0.20* |
TMPRSS2 | r = 0.36*** | r = − 0.04 | r = − 0.10 | r = − 0.06 | r = − 0.07 | r = − 0.06 |
FURIN | r = 0.30*** | r = 0.14 | r = 0.10 | r = 0.24** | r = 0.30*** | r = 0.30*** |
Bronchial biopsy, n = 108 |  |  |  |  |  |  |
ACE2 | r = 0.23* | r = 0.02 | r = − 0.12 | r = − 0.11 | r = 0.01 | r = 0.14 |
TMPRSS2 | r = 0.37*** | r = − 0.14 | r = − 0.30** | r = − 0.14 | r = − 0.01 | r = − 0.01 |
FURIN | r = 0.33*** | r = 0.26** | r = 0.06 | r = 0.20* | r = 0.23* | r = 0.15 |