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Table 2 Summary of correlations between SARS-CoV-2 entry-related gene expression and asthma-associated gene signatures

From: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

  Asthma-associated gene signature
  IL13 Th2 Eosinophils Th17 Neutrophil IL-6-TS Inflammasome
Sputum, n = 120       
ACE2 r = 0.38*** r = 0.18* r = − 0.23* r = 0.02 r = 0.14 r = 0.07
TMPRSS2 r = 0.57*** r = 0.15 r = − 0.06 r = 0.03 r = 0.02 r = 0.10
FURIN r = 0.10 r = 0.13 r = − 0.16 r = 0.51*** r = 0.54*** r = 0.49***
Bronchial brushing, n = 149       
ACE2 r = 0.12 r = − 0.07 r = − 0.11 r = 0.0005 r = 0.11 r = 0.20*
TMPRSS2 r = 0.36*** r = − 0.04 r = − 0.10 r = − 0.06 r = − 0.07 r = − 0.06
FURIN r = 0.30*** r = 0.14 r = 0.10 r = 0.24** r = 0.30*** r = 0.30***
Bronchial biopsy, n = 108       
ACE2 r = 0.23* r = 0.02 r = − 0.12 r = − 0.11 r = 0.01 r = 0.14
TMPRSS2 r = 0.37*** r = − 0.14 r = − 0.30** r = − 0.14 r = − 0.01 r = − 0.01
FURIN r = 0.33*** r = 0.26** r = 0.06 r = 0.20* r = 0.23* r = 0.15
  1. Association of ACE2, TMPRSS2, and FURIN expression with asthma-associated gene signatures were measured and tested using Spearman’s rank-order correlation. Statistically significant correlations are marked bold and also indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001. Otherwise non-significant (p > 0.05). IL-6-TS, IL-6-trans-signalling