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Table 3 Factors associated with persistent sputum production at baseline: comparative and multivariable analyses

From: Gastroesophageal reflux disease is a risk factor for sputum production in the general population: the Nagahama study

Baseline factors

Persistent sputum

n = 1609

Transient sputum

n = 1022

p value

OR (95% CI) for persistent sputum

p value

Age, yeara

54.9 ± 13.3

53.6 ± 13.8

0.01

1.10 (1.04–1.17)

0.002

Male sex, %

50.4

40.6

< 0.0001

1.35 (1.10–1.65)

0.004

BMI, kg/m2

22.6 ± 3.3

22.5 ± 3.4

0.4

  

Smoking history (ex or current), %

49.8

40.9

< 0.0001

1.28 (1.04–1.56)

0.02

COPD, %

2.1

1.5

0.3

  

Asthma, %

6..6

5.5

0.2

  

Allergic rhinitis, %

39.0

37.0

0.3

  

Sinusitis, %

15.7

12.5

0.02

1.17 (0.92–1.48)

0.2

Post-nasal drip, %

35.5

28.8

0.0003

1.40 (1.16–1.67)

0.0003

Diabetes mellitus, %

7.1

6.5

0.5

  

FSSG scores ≥ 8, %

36.5

26.7

< 0.0001

1.58 (1.32–1.88)

< 0.0001

Stress, %

74.5

73.3

0.5

  
  1. Transient; sputum production at baseline only. Persistent; sputum production at both baseline and follow-up assessments
  2. OR odds ratio, CI confidence interval, BMI body mass index, COPD chronic obstructive pulmonary disease, FSSG Frequency Scale for Symptoms of Gastroesophageal Reflux Disease
  3. aAge per 10-year increase
  4. For multivariable analysis