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Table 4 Multivariate Cox-proportional hazards ratios and 95% confidence intervals for transplant-free survival

From: Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes

Parameter

Univariate

Multivariate

HR

95% CL

p

HR

95% CL

p

Age, per 5 years

0.88

0.77–1.00

0.056

0.90

0.76–1.06

0.21

Male

1.64

0.96–2.79

0.068

2.37

1.26–4.46

0.008

Hx of smoking

0.97

0.66–1.42

0.871

0.93

0.57–1.53

0.07

BMI

0.99

0.95–1.03

0.721

0.95

0.90–1.01

0.08

FVC ≥ 47%

0.66

0.46–0.94

0.023

0.57

0.37–0.88

0.01

DLco ≥ 27%

0.89

0.62–1.29

0.540

0.84

0.54–1.29

0.42

Oxygen use

1.72

1.19–2.49

0.004

1.55

0.99–2.43

0.058

6MWD, per 50 m

0.95

0.86–1.05

0.335

0.95

0.85–1.08

0.48

Antifibrotic therapies

0.48

0.32–0.71

< 0.001

0.51

0.33–0.80

0.003

  1. HR: hazard ratio; CL: confidence limit; BMI: body mass index; FVC%: forced vital capacity, % predicted; DLco%: single breath diffusing capacity for carbon monoxide, % predicted; FVC% and DLco% stratified by median (FVC: 47%; DLco: 28%); 6MWD: 6-min walk test distance, meters
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Respiratory Research

ISSN: 1465-993X

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