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Fig. 5 | Respiratory Research

Fig. 5

From: Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

Fig. 5

Alteration of phosphorylated PI3K/Akt/mTOR and PKC/MAPK proteins by RELM-β. Immunohistochemical analysis of phosphorylated PI3K/Akt/mTOR and PKC/MAPK proteins in lung tissue (positive signals in pulmonary arteries were used for analysis); the black arrows indicate that these phosphorylated proteins occur in remolded pulmonary arteries (scale bar: 200 μm) (a). The IOD value of phosphorylated PI3K/Akt/mTOR in different groups (b). The IOD value of phosphorylated PKC/MAPKs in different groups (c). n = 6 rats in each group; the number of vessels counted is ≥ 20 for each bar. *P < 0.05 versus the Normoxia + Lv-NC group. #P < 0.05 versus the Hypoxia + Lv-NC group

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