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Fig. 3 | Respiratory Research

Fig. 3

From: Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

Fig. 3

Effects of RELM-β on HPH and cardiac and pulmonary artery remodeling. Rat pulmonary tissues were observed over 21 days after intratracheal gene transfer with Lenti6.3-EGFP (1.5 × 108 transducing units in a total volume of 150 μl at a daily dose of 50 μl for 3 days). The transfection efficiency was indicated by the green fluorescence in the lung tissues (the white arrows show that EGFP was abundantly expressed in lung tissues and blood vessels) (a). The relative mRNA level of RELM-β in different treatment groups (b). The WB results of RELM-β and the relative protein expression level of RELM-β in different treatment groups (c). The mean pulmonary arterial pressure of rats in different groups (d). The RV/LV + S ratio in rats in different groups (e). n = 6 rats in each group. *P < 0.05 versus the Normoxia + Lv-NC group; **P < 0.01 versus the Hypoxia + Lv-NC group

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Respiratory Research

ISSN: 1465-993X

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