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Fig. 2 | Respiratory Research

Fig. 2

From: Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

Fig. 2

Expression pattern of RELM-β in tissues from an HPH rat model. WB analysis of RELM-β protein expression in rat pulmonary tissue of the control group, H7 group, H14 group and H21 group (a). Quantitative real-time PCR (RT-PCR) results of RELM-β mRNA expression in pulmonary artery muscle at different durations of hypoxia (b). Enzyme-linked immunosorbent assay (ELISA) analysis showing that the serum concentration of RELM-β protein continued to rise, but in the bronchial alveolar lavage fluid, the concentration showed a trend of first increasing and then decreasing, probably due to its paracrine characteristics and regional differences (c). Immunofluorescence colocalization of RELM-β and α-SMA after exposure to hypoxia suggests that RELM-β is expressed in pulmonary arteries (white arrow: pulmonary artery smooth muscle, 400 ×) (d). PB, peripheral blood. n ≥ 6 in each group. *P < 0.05 versus the control group; **P < 0.01 versus the control group; #P < 0.05 versus group H7; △P < 0.05 versus group H14

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Respiratory Research

ISSN: 1465-993X

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