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Fig. 8 | Respiratory Research

Fig. 8

From: Bone marrow mesenchymal stem cells derived miRNA-130b enhances epithelial sodium channel by targeting PTEN

Fig. 8

A schematic diagram highlighting the regulation of ENaC by miR-130b involved in MSCs co-cultured AT2 cells. MiR-130b secreted from MSCs cultured in transwell inserts can bind directly to PTEN, which down-regulates PTEN and inhibits the PIP3 dephosphorylation to PIP2. Increased PIP3 can activate AKT, and increase the mRNA/protein expression and function of ENaC in alveolar epithelial cells. MSCs mesenchymal stem cells, ENaC epithelial sodium channel, PTEN phosphatase and tensin homolog deleted on chromosome ten, PIP2 phosphatidylinositol (4,5)-bisphosphate, PIP3 phosphatidylinositol (3,4,5)-trisphosphate, AKT protein kinase B, AT2 alveolar type 2 epithelial cells

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Respiratory Research

ISSN: 1465-993X

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