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Table 1 Baseline characteristics and clinical data of the study population

From: Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan

Parameter All patients Pirfenidone Placebo
(n = 267) (n = 163) (n = 104)
Gender    
 Male, n (%) 213 (79.8%) 132 (81.0%) 81 (77.9%)
 Female, n (%) 54 (20.2%) 31 (19.0%) 23 (22.1%)
Age, year 64.8 (6.9) 64.9 (6.7) 64.7 (7.3)
  (n = 267) (n = 163) (n = 104)
BMI 24.3 (3.0) 24.1 (2.9) 24.6 (3.2)
  (n = 267) (n = 163) (n = 104)
Smoking    
 Current and former, n (%) 212 (79.4%) 129 (79.1%) 83 (79.8%)
 Never, n (%) 55 (20.6%) 34 (20.9%) 21 (20.2%)
Dyspnea scale (modified by Fletcher)
 1, n (%) 53 (19.9%) 33 (20.2%) 20 (19.2%)
 2, n (%) 143 (53.6%) 80 (49.1%) 63 (60.6%)
 3, n (%) 71 (26.6%) 50 (30.7%) 21 (20.2%)
 4 and 5, n (%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
PaO2, Torr 80.7 (9.6) 80.5 (9.6) 81.0 (9.5)
  (n = 265) (n = 161) (n = 104)
AaDO2, Torr 17.7 (10.3) 17.9 (10.7) 17.4 (9.7)
  (n = 265) (n = 161) (n = 104)
Lowest SpO2 during a 6MET, % 89.0 (2.2) 89.0 (2.3) 89.0 (2.0)
  (n = 266) (n = 162) (n = 104)
VC, L 2.44 (0.67) 2.41 (0.65) 2.47 (0.70)
  (n = 265) (n = 161) (n = 104)
%VC, % 77.8 (17.4) 76.9 (17.4) 79.1 (17.4)
  (n = 265) (n = 161) (n = 104)
%DLCO, % 53.6 (17.8) 52.6 (17.6) 55.2 (18.2)
  (n = 264) (n = 161) (n = 103)
Serum SP-D, ng/mL 238.8 (156.8) 231.6 (140.8) 250.1 (179.1)
  (n = 267) (n = 163) (n = 104)
Serum SP-A, ng/mL 93.2 (51.6) 92.5 (43.8) 94.3 (62.0)
  (n = 267) (n = 163) (n = 104)
Serum KL-6, U/mL 1317.0 (800.3) 1318.2 (803.1) 1315.0 (799.6)
  (n = 267) (n = 163) (n = 104)
  1. Data are presented as n (%), or mean (SD)
  2. BMI body mass index, PaO2 partial pressure of oxygen in arterial blood, AaDO2 alveolar–arterial oxygen difference, SpO2 peripheral capillary oxygen saturation, 6MET 6-min steady-state exercise test, VC vital capacity, DLCO diffusion capacity of the lung for carbon monoxide, SP surfactant protein, KL Krebs von den Lungen