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Fig. 5 | Respiratory Research

Fig. 5

From: ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia

Fig. 5

SOX9 spatiotemporal distribution in normal and hypoplastic lungs. a Representative immunohistochemical evidence SOX9 expression along the normal (ctrl, aA–aH); and hypoplastic (hyp, aa–ah) fetal lung development, from E13.5-to-E21.5. Symbols in each figure identify the distinct pulmonary structures: *bronchi; ¤primordia of bronchiole; ¥terminal bronchiole; {bronchioalveolar duct junction; &alveolar duct. Data is representative of n ≥ 3 independent experiments per stage/protein. b SOX9 stained cells quantified by pulmonary structure and developmental stage. Results are presented as mean ± SEM. Symbols indicate the main effects and non-redundant interactions of one-way ANOVA. αp < 0.05. Scale bar 50 µm

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Respiratory Research

ISSN: 1465-993X

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