Fig. 2From: ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic herniaROBO1 expression profile in normal and hypoplastic lungs. a representative immunohistochemical evidence for the presence of ROBO1 during normal (aA–aH) and hypoplastic (hyp, aa–ah) fetal lung development at the distinct gestational ages. Symbols in each figure identify the distinct pulmonary structures: *bronchi; ¤primordia of bronchiole; ¥terminal bronchiole; {bronchioalveolar duct junction; &alveolar duct. Data is representative of n ≥ 3 independent experiments per stage/protein. b ROBO1 stained cells quantified by pulmonary structure and developmental stage. Results are presented as mean ± SEM. Symbols indicate the main effects and non-redundant interactions of one-way ANOVA. αp < 0.05. Scale bar 50 µmBack to article page