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Table 2 Respiratory parameters and sleep quality during the night with fixed vs. EFLT-abolishing-EPAP

From: Effect of nocturnal EPAP titration to abolish tidal expiratory flow limitation in COPD patients with chronic hypercapnia: a randomized, cross-over pilot study

  Fixed-EPAP EFLT-abolishing-EPAP p
Gas exchange    
mean PtcCO2, mmHg 54.5 (51.1, 59.0) 44.9 (41.6, 57.2) 0.365
T hypercapnia, % 98 (94, 100) 62 (8, 100) 0.031
Mean SpO2, % 93 (92, 95) 94 (93, 95) 0.204
T90, % 3 (0, 12) 1 (0, 2) 0.175
Respiratory parameters  
RINSP, cmH2O*s/L 9.7 (8.5, 12.0) 11.4 (9.3, 12.1) 0.577
XINSP, cmH2O*s/L − 3.6 (− 4.1, − 2.3) − 3.8 (− 3.9, − 2.9) 0.898
IPAP, cmH2O 15.7 (14.0, 17.1) 16.1 (14.3, 18.1) 0.638
VT, mL 356 (252, 542) 272 (230, 395) 0.032
RR, bpm 16 (13, 18) 17 (14, 20) 0.019
VE, L/min 5.3 (3.9, 6.4) 4.6 (3.8, 5.8) 0.123
IE, n/h 261 (205, 351) 126 (93, 205) 0.003
  1. Data are reported as median (IQR)
  2. Bold denotes a statistically significant difference between the fixed-EPAP and the EFLT-abolishing-EPAP nights (Wilcoxon signed-rank test, p < 0.05)
  3. PtcCO2 transcutaneous partial pressure of CO2, T hypercapnia percentage of time spent with a transcutaneous partial pressure of CO2 > 45 mm Hg, SpO2 peripheral oxygen saturation, T90 percentage of time spent with oxygen saturation SpO2 below 90%, RINSP inspiratory resistance, XINSP inspiratory reactance, IPAP inspiratory positive airway pressure, VT tidal volume, RR respiratory rate, VE minute ventilation, IE ineffective efforts
  4. *p < 0.05 vs. fixed-EPAP