Treatment-related biomarkers in pulmonary hypertension patients on oral therapies

Respiratory Research

Table 2 Relationship between 6MWD and Same-visit Biomarkers

Biomarker^a	Estimate	Standard error	p-value
ET-1 (N = 55)	− 44.94	18.19	0.016
NTproBNP (N = 55)
Log(NTproBNP + 1) ≤ 5.5, per 1 unit increase	− 4.67	7.37	0.53
Log(NTproBNP + 1) > 5.5, per 1 unit increase	− 31.25	8.71	0.0006
RDW (N = 55)	− 184.04	71.37	0.012
cGMP (N = 54)	1.78	10.57	0.87
SNO-Hb (N = 50)	1303.27	2822.37	0.64
cGMP/NTproBNP ratio (N = 53)
Log(cGMP/NTproBNP + 1) ≤ 0.3, per 1 unit increase	180.89	82.37	0.032
Log(cGMP/NTproBNP + 1) > 0.3, per 1 unit increase	27.23	27.30	0.32
NO₂⁻ (N = 49)	7.47	6.75	0.28
SDMA (N = 54)
Log(SDMA + 1) ≤ 6, per 1 unit increase	5.82	46.70	0.90
Log(SDMA + 1) > 6, per 1 unit increase	− 46.96	25.25	0.067
ADMA (N = 54)^b
ADMA, PAH on treatment with ERA	− 0.22	0.087	0.012
ADMA, PAH on treatment with PDE5i	− 0.035	0.11	0.75
ADMA, PAH on treatment with ERA + PDE5i	0.098	0.088	0.27

^aAll biomarkers are transformed as log(biomarker + 1) with the exception of ADMA. All models were adjusted for age
^bInteraction p = 0.038

ISSN: 1465-993X