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Table 1 Baseline patient characteristics and biomarker values

From: Treatment-related biomarkers in pulmonary hypertension patients on oral therapies

 

Overall

N = 58

On therapy with ERA

N = 16

On therapy with PDE5i or sGCa

N = 17

On therapy with ERA + PDE5ib

N = 25

Age (years)

61.1 (46.1, 68.5)

61.6 (51.0, 68.1)

69.1 (61.1, 76.4)

51.2 (37.7, 63.9)

Female

52 (89.7%)

16 (100.0%)

14 (82.4%)

22 (88.0%)

Years since PAH diagnosis

6.7 (2.3, 10.7)

7.5 (2.8, 12.0)

5.9 (1.2, 10.9)

6.8 (2.7, 10.0)

6MWD (m)

427.9 (362.1, 487.4)

(N = 54)

413.8 (359.1, 461.0)

427.9 (351.1, 460.9)

(N = 15)

457.2 (369.0, 526.7)

(N = 23)

mPAP (mmHg)

40.3 (27.0, 49.3)

(N = 35)

39.8 (31.8, 48.3)

(N = 12)

29.2 (22.0, 37.0)

(N = 10)

46.7 (40.3, 50.0)

(N = 13)

PVR (WU)

5.1 (3.6, 6.3)

(N = 31)

5.1 (3.9, 6.2)

(N = 11)

3.6 (2.4, 3.7)

(N = 9)

6.0 (5.6, 6.9)

(N = 11)

DLCO (% predicted)

65.5 (53.0, 77.0)

(N = 30)

53.0 (46.0, 72.0)

(N = 10)

62.0 (53.0, 95.0)

(N = 9)

77.0 (53.0, 94.0)

(N = 11)

RVSP (mmHg)

50.0 (36.0, 61.0)

(N = 31)

57.0 (31.0, 73.0)

(N = 7)

37.0 (22.0, 49.0)

(N = 11)

60.0 (47.0, 62.0)

(N = 13)

ET-1 (pg/mL)

2.7 (2.3, 5.1)

(N = 50)

3.1 (2.3, 3.9)

(N = 14)

2.2 (1.8, 2.7)

(N = 15)

4.4 (2.5, 6.0)

(N = 21)

NT-proBNP (pg/mL)

289.0 (119.0, 592.0)

(N = 53)

386.0 (119.0, 661.0)

(N = 15)

264.0 (89.5, 541.0)

(N = 16)

297.0 (125.0, 592.0)

(N = 22)

RDW (%)

14.6 (13.9, 16.5)

(N = 51)

15.1 (14.2, 16.4)

(N = 15)

14.4 (13.5, 15.0)

(N = 15)

15.4 (14.2, 16.8)

(N = 21)

cGMP (pmoles/mL)

51.0 (36.0, 120.3)

(N = 48)

41.3 (33.1, 109.8)

(N = 13)

60.7 (33.3, 121.3)

(N = 15)

51.0 (39.4, 115.7)

(N = 20)

SNO-Hb (moles SNO/mole Hb)

0.0011 (0.0008, 0.0019)

(N = 36)

0.0008 (0.0005, 0.0011)

(N = 10)

0.0010 (0.0008, 0.0014)

(N = 12)

0.0017 (0.0011, 0.0021)

(N = 14)

cGMP to NTproBNP ratio (pmoles/pg)

0.25 (0.10, 0.63)

(N = 43)

0.23 (0.10, 0.66)

(N = 12)

0.29 (0.05, 0.69)

(N = 14)

0.27 (0.11, 0.41)

(N = 17)

ADMA (nM)

520.0 (446.0, 563.0)

(N = 53)

550.5 (500.0, 556.0)

(N = 14)

526.5 (442.5, 594.0)

(N = 16)

515.0 (432.0, 565.0)

(N = 23)

SDMA (nM)

413.0 (352.7, 493.5)

(N = 50)

352.7 (327.0, 402.2)

(N = 13)

453.6 (411.2, 521.0)

(N = 14)

424.9 (353.6, 500.0)

(N = 23)

NO2- (nM)

51.2 (34.1, 98.2)

(N = 30)

72.6 (41.0, 163.4)

(N = 10)

39.0 (26.5, 53.2)

(N = 8)

46.9 (35.0, 93.0)

(N = 12)

  1. Continuous variables presented as median (25, 75); categorical variables presented as frequency (proportion)
  2. ERA, endothelin receptor antagonist; PDE5i, phosphodiesterase 5 inhibitor; sGC, soluble guanylate cyclase stimulator; PAH, pulmonary arterial hypertension; 6MWD, six minute walk distance; m, meters; mPAP, mean pulmonary artery pressure; PVR, pulmonary vascular resistance; WU, woods units; RVSP, right ventricular systolic pressure
  3. a2/17 (11.8%) patients on therapy with soluble guanylate cyclase stimulator, the remainder on PDE5i
  4. b1/25 (4.0%) on therapy with soluble guanylate cyclase stimulator instead of PDE5i
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Respiratory Research

ISSN: 1465-993X

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