Table 2 Univariate associations between variables from PESI, sPESI, and other laboratory tests and 7-day, 14-day, and 30-day PTE mortalities

N

–

4.45% (22/494)

6.49% (32/493)

9.15% (45/492)

Variables from PESI or sPESI

 Age(years)

61.5 (51, 70)

1.043 (1.008, 1.079) [0.014]

1.044 (1.015, 1.074) [0.003]

1.018 (0.997, 1.039) [0.100]

 Age > 80 years

5.04% (25/496)

3.230 (0.888, 11.740) [0.075]

6.891 (2.635, 18.025) [< 0.001]

4.390 (1.725, 11.171) [0.002]

 Male sex

46.17% (229/496)

1.410 (0.598, 3.327) [0.433]

1.523 (0.740, 3.136) [0.253]

1.489 (0.804, 2.759) [0.206]

 Systolic BP < 100 mmHg

15.52% (77/496)

6.152 (2.564, 14.761) [< 0.001]

4.244 (1.998, 9.014) [< 0.001]

3.916 (2.022, 7.585) [< 0.001]

 Pulse rate ≥ 110 b.p.m

22.18% (110/496)

4.580 (1.922, 10.911) [0.001]

3.399 (1.638, 7.054) [0.001]

3.570 (1.900, 6.705) [< 0.001]

 Temperature < 36 °C

3.63% (18/496)

–

0.897 (0.115, 6.989) [0.917]

0.612 (0.079, 4.727) [0.638]

 Respiratory rate > 30 breaths per min

6.05% (30/496)

3.812 (1.203, 12.079) [0.023]

4.202 (1.580, 11.176) [0.004]

2.712 (1.046, 7.031) [0.040]

 SaO₂ < 90%

23.19% (115/496)

3.583 (1.510, 8.498) [0.004]

2.112 (0.999, 4.465) [0.050]

1.587 (0.813, 3.101) [0.176]

 Altered mental status

17.34% (86/496)

12.306 (4.844, 31.264) [< 0.001]

6.550 (3.124, 13.735) [< 0.001]

5.236 (2.754, 9.957) [< 0.001]

 Chronic heart failure

28.43% (141/496)

3.191 (1.346, 7.565) [0.008]

2.346 (1.137, 4.838) [0.021]

2.155 (1.155, 4.022) [0.016]

 Chronic pulmonary disease

28.63% (142/496)

1.765 (0.737, 4.226) [0.202]

1.761 (0.845, 3.669) [0.131]

1.737 (0.924, 3.265) [0.087]

 Cancer

34.88% (173/496)

1.300 (0.544, 3.106) [0.555]

1.709 (0.831, 3.512) [0.145]

1.913 (1.033, 3.544) [0.039]

 History of chronic heart failure or chronic pulmonary disease

42.54% (211/496)

3.017 (1.208, 7.539) [0.018]

2.048 (0.987, 4.246) [0.054]

1.938 (1.042, 3.605) [0.037]

Continuous variables from laboratory tests

 Serum calcium

2.14 (2.04, 2.23)

0.005 (0.000, 0063) [< 0.001]

0.010 (0.001, 0.087) [< 0.001]

0.035 (0.005, 0.230) [0.001]

 Calcium (albumin adjustment)

2.29 (2.22, 2.38)

0.397 (0.009, 18.354) [0.637]

0.767 (0.038, 15.390) [0.862]

0.923 (0.078, 10.859) [0.949]

 cTnI

0.0235 (0.0090, 0.1190)

1.017 (0.962, 1.076) [0.546]

1.020 (0.974, 1.068) [0.402]

1.012 (0.965, 1.060) [0.629]

 NT-proBNP

561 (150, 2114.75)

1.000 (1.000, 1.000) [0.021]

1.000 (1.000, 1.000) [0.002]

1.000 (1.000, 1.000) [0.009]

 D-dimer

4.96 (2.16, 11.43)

1.019 (1.006, 1.033) [0.005]

1.018 (1.006, 1.031) [0.004]

1.013 (1.001 1.025) [0.034]

 GGT

49 (29.5, 99)

0.965 (0.909, 1.026) [0.253]

0.991 (0.969, 1,013) [0.414]

0.999 (0.991, 1.008) [0.871]

 Cr(umol/L)

69 (57, 85)

1.001 (0.997, 1.004) [0.703]

1.000 (0.996, 1.004) [0.967]

1.001 (0.999, 1.003) [0.473]

 Blood glucose (mmol/L)

6.6 (5.5, 8.875)

1.115 (1.034, 1.203) [0.005]

1.105 (1.032, 1.182) [0.004]

1.081 (1.015, 1.152) [0.015]

 Serum potassium (mmol/L)

3.9 (3.6, 4.2)

2.008 (0.907, 4.443) [0.085]

1.484 (0.752, 2.931) [0.255]

1.455 (0.817, 2.594) [0.203]

 Serum sodium(mmol/L)

138 (136, 140)

0.979 (0.882, 1.087) [0.688]

0.959 (0.880, 1.044) [0.332]

0.937 (0.872, 1.006) [0.074]

 Serum chlorine(mmol/L)

103 (100,106)

0.992 (0.905, 1.089) [0.873]

0.991 (0.918, 1.070) [0.815]

0.961 (0.902, 1.023) [0.215]

Categorical variables by thresholding significantly associated continuous variables from laboratory tests

 Hypocalcemia

49.48% (239/483)

3.174 (1.135, 8.877) [0.028]

3.591 (1.511, 8.538) [0.004]

2.858 (1.430, 5.711) [0.003]

 High NT-proBNP

38.64% (153/396)

4.109 (1.418, 11.909) [0.009]

2.750 (1.213, 6.231) [0.015]

2.570 (1.288, 5.128) [0.007]

 High D-dimer

63.45% (302/479)

5.862 (1.349, 25.474) [0.018]

5.880 (1.761, 19.638) [0.004]

3.237 (1.424 7.524) [0.005]

 High blood glucose (mmol/L)

43.18% (209/484)

2.566 (1.005, 6.550) [0.049]

2.079 (0.978, 4.420) [0.057]

1.753 (0.933, 3.296) [0.081]