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Table 2 Diagnostic performance of tumor biomarkers in pleural fluid of lung cancer-associated MPE

From: Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion

  Sensitivity (%) Specificity (%) Criterion AUC P
CEA      
PF 89.8 98.6 5.23 ng/ml 0.978  < 0.001
Serum 81.4 86.5 2.7 ng/ml 0.900  < 0.001
PF/Serum 82.5 86.5 1.365 0.896  < 0.001
CYFRA 21-1      
PF 67.9 90.5 31.39 ng/ml 0.853  < 0.001
Serum 77.7 73.0 2.09 ng/ml 0.812  < 0.001
PF/Serum 80.1 45.9 4.38 0.675  < 0.001
SCC-Ag      
PF 69.3 54.1 1.9 ng/ml 0.609 0.004
Serum 61.7 56.8 0.6 ng/ml 0.610 0.002
PF/Serum 70.8 60.8 2.41 0.659  < 0.001
NSE      
PF 69.0 45.9 8.65 ng/ml 0.600 0.007
Serum 50.3 78.4 18.78 ng/ml 0.667  < 0.001
PF/Serum 16.8 93.2 2.41 0.530 0.426
CA125      
PF 61.2 75.7 698.2 ng/ml 0.698  < 0.001
Serum 32.8 82.4 126 ng/ml 0.558 0.098
PF/Serum 30.8 90.5 11.22 0.599 0.005
  1. CEA carcinoembryonic antigen, CYFRA 21-1 cytokeratin 19 fragment, SCC-Ag squamous cells cancer antigen, NSE neuron-specific enolase, CA125 cancer antigen 125, PF pleural fluid, PF/Serum PF value divided by serum value