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Table 2 Diagnostic performance of tumor biomarkers in pleural fluid of lung cancer-associated MPE

From: Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion

 

Sensitivity (%)

Specificity (%)

Criterion

AUC

P

CEA

     

PF

89.8

98.6

5.23 ng/ml

0.978

 < 0.001

Serum

81.4

86.5

2.7 ng/ml

0.900

 < 0.001

PF/Serum

82.5

86.5

1.365

0.896

 < 0.001

CYFRA 21-1

     

PF

67.9

90.5

31.39 ng/ml

0.853

 < 0.001

Serum

77.7

73.0

2.09 ng/ml

0.812

 < 0.001

PF/Serum

80.1

45.9

4.38

0.675

 < 0.001

SCC-Ag

     

PF

69.3

54.1

1.9 ng/ml

0.609

0.004

Serum

61.7

56.8

0.6 ng/ml

0.610

0.002

PF/Serum

70.8

60.8

2.41

0.659

 < 0.001

NSE

     

PF

69.0

45.9

8.65 ng/ml

0.600

0.007

Serum

50.3

78.4

18.78 ng/ml

0.667

 < 0.001

PF/Serum

16.8

93.2

2.41

0.530

0.426

CA125

     

PF

61.2

75.7

698.2 ng/ml

0.698

 < 0.001

Serum

32.8

82.4

126 ng/ml

0.558

0.098

PF/Serum

30.8

90.5

11.22

0.599

0.005

  1. CEA carcinoembryonic antigen, CYFRA 21-1 cytokeratin 19 fragment, SCC-Ag squamous cells cancer antigen, NSE neuron-specific enolase, CA125 cancer antigen 125, PF pleural fluid, PF/Serum PF value divided by serum value