The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice

Table 1 Clinical and demographic characteristics of ARDS patients and normal subjects

Characteristics	ARDS patients (n = 40)	Healthy controls (n = 40)	P
Male, n (%)^a	28 (70.0)	25 (62.5)	0.48
Age (years) ^b	67 (55–74)	62 (57–64)	0.13
Etiology, n (%)		N/A
Pneumonia	25 (62.5)
Abdominal infection	15 (37.5)
Underlying diseases, n (%)		N/A
Hypertension	18 (45.0)
Chronic respiratory disease	2 (5.0)
PaO2/FiO2 ratio, n (%)		N/A
200–300	8 (20.0)
100–200	20 (50.0)
≦100	12 (30.0)
CRP (mg/dl)	12.0 (8.7–17.1)	N/A
PCT (ng/ml)	2.7(0.7–18.4)	N/A
APACHE II score	15 (11–24)	N/A
SOFA score	7 (4–10)	N/A
Complications, n (%)		N/A
Liver disfunction	20 (50.0)
Acute kidney injury	7 (17.5)
Treatment during ICU, n (%)		N/A
Vasopressor	24 (60.0)
Parenteral nutrition	18 (45.0)
Sedative	31 (77.5)
IMV days	16 (9–32)	N/A
28-day mortality, n (%)	13 (32.5)	N/A

PaO2 arterial oxygen tension, FiO2 fraction of inspired oxygen, CRP C-reactive protein, PCT procalcitonin, APACHE II, Acute Physiology and Chronic Health Evaluation II, SOFA sequential organ failure assessment, IMV invasive mechanical ventilation
^aChi-square test
^bMann–Whitney U test

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